Anti-CD40 Antibody

Christian Larsen, MD

An Emory surgeon developed a new monoclonal antibody against the B cell antigen CD40 that, upon binding, is capable of blocking the signaling interaction of CD40 with its ligand, CD154, on T cells. By blocking B cell activation and inducing immunosuppression, this antibody may reduce the likelihood of, or increase the duration prior to, transplant rejection or be used to treat autoimmune disorder. Emory licensed this technology to Primatope Therapeutics, Inc. in 2013.